There have been multiple research studies focused on the physiological risk factors of stroke.
Florez, Ay, Van Cott, and Buonanno (2003) conducted their retrospective study to find a relationship between patent foramen ovale (PFO) and a hypercoagulate state to determine whether having this physiological condition could become a health burden affecting the development of stroke and prevent coagulation. The patients’ medical history was used to note that there was approximately an equal percentage of patients tested for either patent foramen ovale (PFO) or for a hypercoagulate state. In addition, the percentage of patients tested for both conditions was nearly the same as those who were tested for a hypercoagulate state without having patent foramen ovale. In conclusion, both health conditions were considered risk factors for stroke having different effects on the outcome of stroke when they were tested intermittently (Florez, Ay, Van Cott, ; Buonanno, 2003).
PFO was also identified as physiological risk factor for stroke in a prospective study by Meissner, et al. (1999). Cardiovascular and cerebrovascular diseases were examined using two protocols consisting of transesophageal echocardiography as well as carotid ultrasonography.
These protocols were deemed efficient in finding that stroke could be prevented by addressing certain risk factors such as patent foramen ovale, atrial septal aneurysm, aortic atherosclerosis, strands on native valve, carotid occlusion diseases, and stenosis using demographics data to conduct the study of stroke (Meissner et al., 1999). These finding suggest physiological factor play a significant role in determining stroke outcome.